Genetics

This blog post examines multiple sclerosis through an integrated scientific framework that connects genetic susceptibility, metabolomic alterations, genome-wide association studies, and polygenic risk scores. Drawing on recent findings from peer-reviewed journals, it explains how GWAS has mapped the polygenic architecture of MS, how PRS can quantify inherited risk, and how circulating and tissue-level metabolites may illuminate causal pathways, disease activity, and progression. The article highlights the growing importance of multi-omic approaches in moving MS research toward biologically informed prediction and precision neurology.