Genetics

This post takes the mechanistic half of Oppong and colleagues' 2024 iScience study, the whole blood transcriptomics and the gene-metabolite network, rather than the classifier. It walks through the enrichment ratios putting pyruvate metabolism and ketone body synthesis at the top, the 1,052 differentially expressed genes and the pathway that appears in both directions, the four blocks of the gene-metabolite network and the phenylalanine node imported from earlier literature, the position of GOT2 across six metabolic processes, the independent dataset the pathways were checked against, and why the proposed chain from metabolic switch to neurodegeneration remains untested in a cross-sectional design.