Genetics

This post reads Ladakis and colleagues' 2024 metabolomic study of MS brain lesions through its bioenergetic rather than its lipid findings. It follows the energy module falling at a standardized mean difference of -0.31 and the nucleotide module at -0.28 while the acylcarnitines do not move at all, the energy reduction present in periplaque tissue that is not demyelinated and what the authors make of that for lesion expansion, the opposite direction taken by dipeptides and amino acids, the three candidate causes the authors offer as speculation, the placement of pantothenate and coenzyme A metabolites with the promyelinating rather than the inflammatory cell block, and the limitations that bear on whether any of this is cause or consequence.