Genetics

This blog post examines how the genetic study of multiple sclerosis remains incomplete without broader inclusion of populations of non-European ancestry. Drawing on Jacobs and colleagues’ Perspective article, it explains why diverse genomic research is essential for clarifying global differences in MS risk, improving fine mapping of causal variants, strengthening polygenic risk prediction, and reducing inequities in precision medicine. The post highlights the scientific value of cross-ancestral studies, particularly in understanding the MHC region, identifying novel susceptibility loci, and distinguishing genetic influences from environmental and social determinants of disease.