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Silent Progression, Silent Signal: Rethinking Neurofilament Light as a Marker of Treatment Response in Progressive MS
Silent Progression, Silent Signal: Rethinking Neurofilament Light as a Marker of Treatment Response in Progressive MS

This blog post explores a scientific approach to understanding why some multiple sclerosis (MS) patients respond well to interferon-beta (IFN-β) therapy while others do not. Rather than focusing on individual gene activity, the study spotlights how relationships between genes—how they “talk” to each other—change over time in responders versus non-responders. Using a method that tracks these dynamic gene pair interactions, researchers identified a set of genes whose behavior strongly predicts treatment success. This humanized look at complex gene networks not only deepens our understanding of how IFN-β works but also opens the door to more personalized, effective MS care.

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