Genetics

A metabolome-wide Mendelian randomization study has identified 29 circulating metabolites that may contribute causally to multiple sclerosis risk. By integrating large-scale genetic data with blood metabolomic profiles, the researchers highlighted potential roles for amino acids such as serine and lysine, ketone bodies including acetone and acetoacetate, and distinct lipid components within VLDL and HDL particles. The findings offer new insight into the metabolic architecture of multiple sclerosis while providing a focused foundation for future biomarker research, mechanistic studies, and therapeutic development.