Genetics

This post covers Preziosa and colleagues' 2026 study in Neurology: Neuroimmunology & Neuroinflammation as an imaging-genetics design. It follows the construction of a residual quantitative phenotype from a normative lifespan model in 461 controls, the evidence that brain and ventricular anatomy rather than age determines choroid plexus volume, the three properties that make the z-score usable as a trait in 727 MS patients, which clinical and imaging axis the trait loads on, and the central genetic result that plexus enlargement tracks a cumulative HLA Genetic Burden score across 24 loci while none of three non-HLA polygenic risk scores and no single locus including HLA-DRB1*15:01 shows an effect, closing on the genetic limitations that bound the inference.