Genetics

This post covers Djuric and colleagues' 2025 study in International Journal of Molecular Sciences, which tested seven regulatory gene variants against MS severity in 845 Serbian patients. It covers the documented five-criterion variant selection, the sex-specific MAP1B rs62363242 association with progressive disease and its reported 62% power, the same variant's link to lower serum iron and higher transferrin, CDKN1A haplotypes tracking with both gene expression and EDSS, where the two published severity GWAS variants landed including the opposite-direction MTSS1 result the authors explain by study design, and the validation work the authors identify as necessary.