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The Role of Gene-Environment and Gene-Gene Interactions in IQ Heritability

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Gene-Environment Relationship and Gene-Gene Interaction in Heritability of IQ Gene-environment interaction (GxE) refers to the interplay between genetic factors and environmental influences, where genetic sensitivity to the environment plays a crucial role. This interaction is significant in understanding how environmental factors can impact complex traits like IQ, especially when considering the individual's genetic makeup. The effect of gene-gene interaction, also known as locus-locus interaction, is essential in calculating the heritability of complex traits like IQ. Definition of IQ and Factors Influencing IQ IQ, or Intelligence Quotient, is a measure of an individual's cognitive abilities relative to others. It is influenced by both genetic and environmental factors. Twin studies have been instrumental in determining the heritability of IQ. These studies show that genetics play a substantial role in IQ variances, with estimates suggesting heritability percentages ranging from 50% to 80%. Twin Studies and Environmental Factors Impacting IQ Twin studies provide valuable insights into the heritability of complex traits like IQ by comparing identical twins (who share 100% of their genes) with fraternal twins (who share around 50% of their genes). By studying twins raised in different environments, researchers can disentangle genetic and environmental influences on traits like IQ. Environmental factors such as socio-economic status, exposure to toxins, air quality, and parenting styles can also impact IQ. Environmental factors play a significant role in influencing an individual's Intelligence Quotient (IQ). These factors can have both short-term and long-term effects on cognitive development. Here are some key environmental influences on IQ based on the provided search results: Place of Residence: Children living in cities tend to have higher IQ scores compared to those in rural areas. Physical Activity: Regular physical activity, with more than 5 hours per week, is associated with higher IQ levels in children. Family Income: Higher family income is linked to increased IQ levels in children. Parental Education and Occupation: Children with parents who have higher levels of education and professional occupations tend to have higher IQ scores. Nutrition: Early nutrition plays a crucial role in brain development and can impact IQ levels. Malnutrition during early childhood can lead to a reduction in IQ by up to 15 points. Cognitive Stimulation at Home: The level of cognitive stimulation a child receives at home, including the quality of interactions with parents, influences IQ development. Quality of Education: The school environment and the quality of teaching can affect IQ levels in children. Social Factors: Factors like exposure to environmental toxins, micronutrient deficiencies, and socio-economic status can also impact intelligence adversely. Mental Stress: Living in environments with high mental stress has been associated with lower IQ levels in children. In conclusion, gene-environment interactions and gene-gene interactions play crucial roles in understanding the heritability of complex traits like IQ. Twin studies have been informative in dissecting genetic and environmental influences on IQ, highlighting the significant impact of both nature and nurture on cognitive abilities. References:

Plomin, R., Gidziela, A., Malanchini, M., & Von Stumm, S. (2022). Gene–environment interaction using polygenic scores: Do polygenic scores for psychopathology moderate predictions from environmental risk to behavior problems?. Development and psychopathology, 34(5), 1816-1826. Makharia, A., Nagarajan, A., Mishra, A., Peddisetty, S., Chahal, D., & Singh, Y. (2016). Effect of environmental factors on intelligence quotient of children. Industrial psychiatry journal, 25(2), 189. Ghazi, H. F., Isa, Z. M., Aljunid, S., Shah, S. A., Tamil, A. M., & Abdalqader, M. A. (2012). The negative impact of living environment on intelligence quotient of primary school children in Baghdad City, Iraq: a cross-sectional study. BMC Public health, 12, 1-7.