Genetics
HLA Allele, Four Measures of MS Severity27, Sep 2026
Topic hub
Multiple Sclerosis Genetics
Multiple sclerosis is one of the strongest themes on this site. This pillar gathers the genetics, immune biology, progression, and multi-omics posts into one crawlable hub.
Core Questions
Which inherited variants and immune pathways change MS susceptibility?
Which genetic signals help explain disability progression or CNS resilience?
How do proteomics, metabolomics, and Mendelian randomization connect risk to mechanisms?
Topic Clusters
Core Articles
Genetics
HLA Allele, Four Measures of MS Severity
27, Sep 2026This post covers Okuda and colleagues' 2009 Brain study of HLA-DRB1*1501 carrier status against four domains of MS severity in 505 patients at...
Genetics
The MS Severity Variant Shows Up in Brains
26, Sep 2026This post covers Corsten and colleagues' 2026 Annals of Neurology brief communication, which tested the MS progression variant rs10191329*A for...
Genetics
The BDNF Allele That Tracks With More Gray Matter in MS
25, Sep 2026This post covers Zivadinov and colleagues' 2007 Human Molecular Genetics study of the BDNF rs6265 Val66Met polymorphism in 209 treated MS...
Genetics
Two Loci for How MS Progresses, Not Whether It Starts
23, Sep 2026This post covers Loomis and colleagues' 2023 Scientific Reports study, the first GWAS meta-analysis of longitudinal brain MRI measures of MS...
Genetics
Narrowing 1,091 Metabolites Down to One Enzyme in MS
23, Sep 2026This post covers Noroozi and colleagues' 2026 medRxiv preprint, a layered Mendelian randomization study testing 1,091 plasma metabolites and 309...
Genetics
A MAP1B Variant Tracks With Progressive MS in Women
21, Sep 2026This post covers Djuric and colleagues' 2025 study in International Journal of Molecular Sciences, which tested seven regulatory gene variants...
Genetics
Two Approaches to Iron in MS
20, Sep 2026This post covers Tang and colleagues' 2024 study in Frontiers in Immunology, which pairs a bioinformatics analysis of iron metabolism genes in MS...
Genetics
Checking 4,142 MS Clinical Records Against a Research Cohort
19, Sep 2026This post covers Damotte, Lizee and colleagues' study in Multiple Sclerosis Journal, which identified 4,142 MS patients in the UCSF electronic...
Genetics
Three Statistical Models Converge on GRIN2A in MS Brain Volume
18, Sep 2026This post covers Strijbis, Inkster and colleagues' study in Multiple Sclerosis Journal applying sparse reduced-rank regression to glutamate-gene...
Genetics
A Causal Map of MS and the Cortex
18, Sep 2026This post covers Sun and colleagues' 2024 study in Journal of Translational Medicine, the Mendelian randomization analysis of MS and cortical...
Genetics
Where MS Genetics and Vitamin D Converge on One Enzyme Step
17, Sep 2026This post covers Grigorian and colleagues' 2012 review in Seminars in Immunopathology, arguing that genetic variants in IL7RA, IL2RA, MGAT1 and...
Genetics
MS T Cells Carry More Cholesterol and Fewer Glycosphingolipids
16, Sep 2026This post covers Martin-Gutierrez and colleagues' 2024 study in Clinical and Experimental Immunology on lipid metabolism in CD4 T cells from...