Genetics
Vitamin D Receptor Genomics: Connecting Immune Regulation to Multiple Sclerosis29, Jul 2026
Topic hub
Whole Exome Sequencing
Whole exome sequencing content is collected here as a practical hub for variant discovery, filtering, interpretation, and familial genetics workflows.
Core Questions
How should rare variants be filtered and prioritized after WES?
How can segregation evidence strengthen candidate variant interpretation?
Which annotation and pathogenicity signals are useful without overclaiming?
Topic Clusters
Core Articles
Genetics
Rare Coding Variants and the Genetic Basis of Multiple Sclerosis
22, Jul 2026This blog post examines how low-frequency and rare protein-coding variants contribute to multiple sclerosis susceptibility beyond the genetic...
Genetics
Serotonin, Adenosine Metabolism and Multiple Sclerosis: A Multi-Omics Perspective
20, Jul 2026This blog post examines a recent study proposing that elevated serotonin may increase susceptibility to multiple sclerosis by suppressing...
Genetics
Metabolic Remodeling in Multiple Sclerosis: How Lipid Dysregulation Shapes Brain Lesions
17, Jul 2026This blog post examines a multiomic study of multiple sclerosis brain lesions that combines mass spectrometry–based metabolomics with...
Genetics
Genetic Regulation of Cytokine Responses and Its Relevance to Multiple Sclerosis
12, Jul 2026This blog post examines how inherited genetic variation and baseline immune characteristics shape cytokine production in healthy individuals, with...
Genetics
Genetic Risk Scoring for Predicting Multiple Sclerosis After Optic Neuritis
11, Jul 2026This blog post examines a large multicohort study evaluating whether a multiple sclerosis genetic risk score can improve prediction of future...
Genetics
Rare Genetic Variants and Familial Multiple Sclerosis: New Insights from Exome Sequencing
07, Jul 2026This blog post examines a recent Scientific Reports study investigating the role of rare, potentially pathogenic genetic variants in familial...
Genetics
Why European Genetic Risk Scores Fall Short in Predicting Multiple Sclerosis Risk Among South Asian Populations
06, Jul 2026This blog post examines a study published in Brain Communications that evaluates whether European-derived polygenic risk scores can accurately...
Genetics
Polygenic Risk Scores in Multiple Sclerosis: Advancing Genetic Prediction and Disease Stratification
05, Jul 2026This blog post examines a Brain article investigating the role of polygenic risk scores in multiple sclerosis susceptibility and disease phenotype...
Genetics
Rare Genetic Variants and Familial Multiple Sclerosis: Insights from Whole-Exome Sequencing
04, Jul 2026This blog post examines a recent study that used whole-exome sequencing to investigate the genetic basis of multiple sclerosis in a...
Genetics
When MS Genetic Risk Meets Working Memory: Evidence from Healthy Young Adults
30, Jun 2026This blog post examines a recent study investigating whether genetic susceptibility to multiple sclerosis is associated with working memory...
Genetics
Integrating Genetics and Environment to Reveal Causal Mechanisms in Multiple Sclerosis
26, Jun 2026This blog post examines how genetic susceptibility and environmental exposures jointly shape the risk and pathogenesis of multiple sclerosis....
Genetics
Ancient Steppe Ancestry and the Evolutionary Origins of Multiple Sclerosis Risk
23, Jun 2026This blog post examines how ancient population movements and immune adaptation may have shaped the modern genetic risk of multiple sclerosis....