Genetics
How Genes, Lifestyle, and Environment Shape Multiple Sclerosis Risk18, Aug 2026
Topic hub
Whole Exome Sequencing
Whole exome sequencing content is collected here as a practical hub for variant discovery, filtering, interpretation, and familial genetics workflows.
Core Questions
How should rare variants be filtered and prioritized after WES?
How can segregation evidence strengthen candidate variant interpretation?
Which annotation and pathogenicity signals are useful without overclaiming?
Topic Clusters
Core Articles
Genetics
Genetics, Lipids, and Disability Progression in Multiple Sclerosis: Understanding a Gene–Environment Interaction
16, Aug 2026This blog post examines research by Zhang and colleagues investigating how lipid-related genetic variants may influence disability progression in...
Genetics
Genetic Variation in Lipid Metabolism and Multiple Sclerosis Progression: Evidence for a Gene–Environment Interaction
11, Aug 2026This blog post examines research by Zhang and colleagues investigating how lipid-related genetic polymorphisms may influence disability...
Genetics
Genetic Foundations of Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder
08, Aug 2026This blog post examines the genetic and biological mechanisms underlying multiple sclerosis (MS) and neuromyelitis optica spectrum disorder...
Genetics
Mapping Multiple Sclerosis Risk Across Diverse Ancestries
06, Aug 2026This blog post examines a multi-ancestry genetic study of multiple sclerosis susceptibility in people of South Asian and African ancestry living...
Genetics
Myelin Lipids in Multiple Sclerosis: From Membrane Architecture to Immune Regulation and Repair
03, Aug 2026This blog post examines the multifaceted role of myelin lipids in multiple sclerosis, drawing on the review by Podbielska and Hogan. It explains...
Genetics
How Lipid-Related Genetic Variation May Shape Disability Progression in Multiple Sclerosis
02, Aug 2026This blog post examines research showing that the relationship between serum lipids and disability progression in multiple sclerosis may depend...
Genetics
Rare Coding Variants and the Genetic Basis of Multiple Sclerosis
22, Jul 2026This blog post examines how low-frequency and rare protein-coding variants contribute to multiple sclerosis susceptibility beyond the genetic...
Genetics
Serotonin, Adenosine Metabolism and Multiple Sclerosis: A Multi-Omics Perspective
20, Jul 2026This blog post examines a recent study proposing that elevated serotonin may increase susceptibility to multiple sclerosis by suppressing...
Genetics
Metabolic Remodeling in Multiple Sclerosis: How Lipid Dysregulation Shapes Brain Lesions
17, Jul 2026This blog post examines a multiomic study of multiple sclerosis brain lesions that combines mass spectrometry–based metabolomics with...
Genetics
Genetic Regulation of Cytokine Responses and Its Relevance to Multiple Sclerosis
12, Jul 2026This blog post examines how inherited genetic variation and baseline immune characteristics shape cytokine production in healthy individuals, with...
Genetics
Genetic Risk Scoring for Predicting Multiple Sclerosis After Optic Neuritis
11, Jul 2026This blog post examines a large multicohort study evaluating whether a multiple sclerosis genetic risk score can improve prediction of future...
Genetics
Rare Genetic Variants and Familial Multiple Sclerosis: New Insights from Exome Sequencing
07, Jul 2026This blog post examines a recent Scientific Reports study investigating the role of rare, potentially pathogenic genetic variants in familial...