Genetics
HLA Allele, Four Measures of MS Severity27, Sep 2026
Topic hub
Whole Exome Sequencing
Whole exome sequencing content is collected here as a practical hub for variant discovery, filtering, interpretation, and familial genetics workflows.
Core Questions
How should rare variants be filtered and prioritized after WES?
How can segregation evidence strengthen candidate variant interpretation?
Which annotation and pathogenicity signals are useful without overclaiming?
Topic Clusters
Core Articles
Genetics
An Iron-Responsive MS Subtype, Proposed From Two Children
12, Sep 2026This post covers van Rensburg and colleagues' 2019 report in Molecular Genetics and Metabolism Reports, a whole exome sequencing study of two boys...
Genetics
When MS Risk Factors Multiply With Genotype Instead of Adding
09, Sep 2026This post covers Olsson, Barcellos and Alfredsson's 2017 Nature Reviews Neurology review on gene-environment interaction in multiple sclerosis. It...
Genetics
MS Genetic Risk, Healthy Brains, and an Effect Measured in Milliseconds
07, Sep 2026This post covers Feng and colleagues' 2026 study in Magnetic Resonance in Medical Sciences, which tested whether a polygenic risk score for...
Genetics
Twelve Genes, Twenty Years, No Answer: Vitamin D and Genetic Susceptibility to MS
31, Aug 2026This post covers a 2021 Biochemical Genetics review by Scazzone and colleagues on SNPs in 12 vitamin D pathway genes and multiple sclerosis...
Genetics
Genetics, Lipids, and Disability Progression in Multiple Sclerosis: Understanding a Gene–Environment Interaction
16, Aug 2026This blog post examines research by Zhang and colleagues investigating how lipid-related genetic variants may influence disability progression in...
Genetics
Genetic Variation in Lipid Metabolism and Multiple Sclerosis Progression: Evidence for a Gene–Environment Interaction
11, Aug 2026This blog post examines research by Zhang and colleagues investigating how lipid-related genetic polymorphisms may influence disability...
Genetics
Genetic Foundations of Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder
08, Aug 2026This blog post examines the genetic and biological mechanisms underlying multiple sclerosis (MS) and neuromyelitis optica spectrum disorder...
Genetics
Mapping Multiple Sclerosis Risk Across Diverse Ancestries
06, Aug 2026This blog post examines a multi-ancestry genetic study of multiple sclerosis susceptibility in people of South Asian and African ancestry living...
Genetics
Myelin Lipids in Multiple Sclerosis: From Membrane Architecture to Immune Regulation and Repair
03, Aug 2026This blog post examines the multifaceted role of myelin lipids in multiple sclerosis, drawing on the review by Podbielska and Hogan. It explains...
Genetics
How Lipid-Related Genetic Variation May Shape Disability Progression in Multiple Sclerosis
02, Aug 2026This blog post examines research showing that the relationship between serum lipids and disability progression in multiple sclerosis may depend...
Genetics
Rare Coding Variants and the Genetic Basis of Multiple Sclerosis
22, Jul 2026This blog post examines how low-frequency and rare protein-coding variants contribute to multiple sclerosis susceptibility beyond the genetic...
Genetics
Serotonin, Adenosine Metabolism and Multiple Sclerosis: A Multi-Omics Perspective
20, Jul 2026This blog post examines a recent study proposing that elevated serotonin may increase susceptibility to multiple sclerosis by suppressing...