Genetics
The Metabolic Switch in Progressive MS, and How Much of It Is Tested06, Sep 2026
Topic hub
Omics Analysis
This pillar groups omics analysis posts that connect molecular measurements with disease mechanisms, biomarkers, and pathway-level interpretation.
Core Questions
Which molecular layers best explain disease biology?
How can pathway analysis turn high-dimensional results into interpretable mechanisms?
Where do omics findings suggest biomarkers or therapeutic hypotheses?
Topic Clusters
Core Articles
Genetics
The Metabolic Switch in Progressive MS, and How Much of It Is Tested
06, Sep 2026This post takes the mechanistic half of Oppong and colleagues' 2024 iScience study, the whole blood transcriptomics and the gene-metabolite...
Genetics
Same Dose, Different Response: Vitamin D and the MS Metabolome
06, Sep 2026This post covers Bhargava and colleagues' 2017 JCI Insight study, which profiled the plasma metabolome in relapsing-remitting MS patients and...
Genetics
Four Groups of Thirty: NMR Metabolomics Across the MS Subtypes
05, Sep 2026This post covers Alwahsh and colleagues' 2024 Scientific Reports study, which used cryogenic proton NMR to quantify 40 serum metabolites in 30...
Genetics
Two Cohorts, Three Classifiers: Metabolomic Signatures of MS Severity
04, Sep 2026This post covers Villoslada and colleagues' 2017 study in Neurology: Neuroimmunology & Neuroinflammation, which used two Spanish MS cohorts, one...
Genetics
From Metabolite Signature to Drug Target: Glycolysis in Relapsing-Remitting MS
03, Sep 2026This post covers Zahoor and colleagues' 2022 PNAS study, which takes serum metabolomics in treatment-naive relapsing-remitting MS patients through...
Genetics
A Blood Test for Progressive MS? What the Metabolite Signature Actually Shows
02, Sep 2026This post covers Oppong and colleagues' 2024 iScience study using serum NMR metabolomics and whole blood transcriptomics to separate...
Genetics
Metabolism as Medicine: A New Therapeutic Direction for Multiple Sclerosis
01, Sep 2026This post covers Badawi and colleagues' 2026 Inflammopharmacology review on immunometabolic reprogramming in multiple sclerosis. It walks through...
Genetics
Twelve Genes, Twenty Years, No Answer: Vitamin D and Genetic Susceptibility to MS
31, Aug 2026This post covers a 2021 Biochemical Genetics review by Scazzone and colleagues on SNPs in 12 vitamin D pathway genes and multiple sclerosis...
Genetics
Metabolites and Multiple Sclerosis: What Genetic Studies Agree and Disagree On
30, Aug 2026This post compares four Mendelian randomization studies (2023-2025) testing whether circulating and vitamin D metabolites causally affect multiple...
Genetics
Inflammation–Metabolite in Multiple Sclerosis: The Emerging Role of Interleukin-7
29, Aug 2026This scientific blog post examines a 2025 Mendelian randomization study investigating how inflammatory proteins and metabolic pathways may...
Genetics
Decoding Multiple Sclerosis Progression Through Blood Metabolomics and Transcriptomics
28, Aug 2026This blog post examines a 2024 iScience study investigating how blood-based metabolomic and transcriptomic signatures may distinguish...
Genetics
Vitamin D and Genetic Susceptibility to Multiple Sclerosis: Understanding a Complex Biological Connection
26, Aug 2026Multiple sclerosis is a multifactorial autoimmune disease shaped by interactions among genetic, environmental, and immunological factors. This...