Genetics
HLA Allele, Four Measures of MS Severity27, Sep 2026
Topic hub
Omics Analysis
This pillar groups omics analysis posts that connect molecular measurements with disease mechanisms, biomarkers, and pathway-level interpretation.
Core Questions
Which molecular layers best explain disease biology?
How can pathway analysis turn high-dimensional results into interpretable mechanisms?
Where do omics findings suggest biomarkers or therapeutic hypotheses?
Topic Clusters
Core Articles
Genetics
HLA Allele, Four Measures of MS Severity
27, Sep 2026This post covers Okuda and colleagues' 2009 Brain study of HLA-DRB1*1501 carrier status against four domains of MS severity in 505 patients at...
Genetics
The MS Severity Variant Shows Up in Brains
26, Sep 2026This post covers Corsten and colleagues' 2026 Annals of Neurology brief communication, which tested the MS progression variant rs10191329*A for...
Genetics
Narrowing 1,091 Metabolites Down to One Enzyme in MS
23, Sep 2026This post covers Noroozi and colleagues' 2026 medRxiv preprint, a layered Mendelian randomization study testing 1,091 plasma metabolites and 309...
Genetics
Two Approaches to Iron in MS
20, Sep 2026This post covers Tang and colleagues' 2024 study in Frontiers in Immunology, which pairs a bioinformatics analysis of iron metabolism genes in MS...
Genetics
A Causal Map of MS and the Cortex
18, Sep 2026This post covers Sun and colleagues' 2024 study in Journal of Translational Medicine, the Mendelian randomization analysis of MS and cortical...
Genetics
Where MS Genetics and Vitamin D Converge on One Enzyme Step
17, Sep 2026This post covers Grigorian and colleagues' 2012 review in Seminars in Immunopathology, arguing that genetic variants in IL7RA, IL2RA, MGAT1 and...
Genetics
MS T Cells Carry More Cholesterol and Fewer Glycosphingolipids
16, Sep 2026This post covers Martin-Gutierrez and colleagues' 2024 study in Clinical and Experimental Immunology on lipid metabolism in CD4 T cells from...
Genetics
A Modest but Durable Vitamin D Effect on MS Risk
15, Sep 2026This post covers Rhead and colleagues' 2016 study in Neurology: Genetics, a Mendelian randomization analysis using individual-level data from...
Genetics
Glucose Uptake and ATP Synthesis in MS T Cells
14, Sep 2026This post covers Kavaka and colleagues' study of monozygotic twins discordant for multiple sclerosis, in which 193,771 CD8 T cells were sequenced...
Genetics
A STAT3 Variant Marks White Matter Before MS Begins
12, Sep 2026This post covers the Nature Genetics version of Zeng, Khan and colleagues' multi-ancestry MS GWAS, focusing on what the peer-reviewed version adds...
Genetics
An Iron-Responsive MS Subtype, Proposed From Two Children
12, Sep 2026This post covers van Rensburg and colleagues' 2019 report in Molecular Genetics and Metabolism Reports, a whole exome sequencing study of two boys...
Genetics
Reduced FADS1 Activity and How Severe MS Becomes
11, Sep 2026This post covers Noroozi and colleagues' 2026 medRxiv preprint using layered Mendelian randomization to link lipid metabolism to multiple...